{"created":"2024-07-04T05:44:38.598101+00:00","id":2000077,"links":{},"metadata":{"_buckets":{"deposit":"a044ed47-d309-4632-8546-1f4fca74c55a"},"_deposit":{"created_by":4,"id":"2000077","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000077"},"status":"published"},"_oai":{"id":"oai:kait.repo.nii.ac.jp:02000077","sets":["2:16:43:1719997568599"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"神奈川工科大学研究報告.B,理工学編"}]}]},"item_10002_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Escherichia coli chaperonin GroEL is a virtually cylindrical protein complex composed of two heptameric rings with a 4.5 nm cavity in the center that plays an important role in assisting intracellular protein folding in conjunction with GroES and ATP. We are exploring the utility of this unique structural property of chaperonins as capsules that encapsulate a variety of compounds, including drugs, and facilitate their transport into intracellular organelles.\nIn the area of molecular research and drug discovery, docking simulations that predict protein-ligand binding interactions have recently become of significant value. This computational approach plays a critical role in speeding up the identification of potential drug candidates and improving our  understanding of the fundamental interactions between proteins and small molecules. It stands out as the preferred method for in silico evaluation of protein-ligand binding dynamics because it allows binding predictions that are often not feasible in real experiments. We employed this method, which can predict binding interactions that cannot be determined by experimental methods alone, for in silico evaluation of proteinligand binding dynamics to infer the potential of chaperonins as carriers in drug delivery systems (DDS).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.34411/0002000077","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"神奈川工科大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12669200","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21882878","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"依田, ひろみ","creatorNameLang":"ja"},{"creatorName":"Yoda, Hiromi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"河崎, 佑輔","creatorNameLang":"ja"},{"creatorName":"Kawasaki, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小池, あゆみ","creatorNameLang":"ja"},{"creatorName":"Koike-Takeshita, Ayumi ","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-07-03"}],"displaytype":"detail","filename":"kkb-048-001.pdf","filesize":[{"value":"1.61 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kkb-048-001.pdf","objectType":"fulltext","url":"https://kait.repo.nii.ac.jp/record/2000077/files/kkb-048-001.pdf"},"version_id":"a3e2df43-3604-423b-83f3-052fe54fa537"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Docking simulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GroEL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chaperonin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug delivery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DDS","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"シャペロニンとリガンドの結合における分子ドッキングアプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"シャペロニンとリガンドの結合における分子ドッキングアプローチ","subitem_title_language":"ja"},{"subitem_title":"Molecular docking approaches in chaperonin-ligand binding","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"4","path":["1719997568599"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-07-03"},"publish_date":"2024-07-03","publish_status":"0","recid":"2000077","relation_version_is_last":true,"title":["シャペロニンとリガンドの結合における分子ドッキングアプローチ"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-07-05T06:16:28.063481+00:00"}